2025
- Deeper insight into speech characteristics of patients at ultra-high risk using classification and explainability models
Deok-Hee Kim-Dufor, Michel Walter, Marie-Odile Krebs, Yannis Haralambous, Philippe Lenca, Christophe Lemey
Front. Psychiatry, 16 June 2025 Sec. Schizophrenia,Volume 16 – 2025 | https://doi.org/10.3389/fpsyt.2025.1595197
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1595197/full -
Oxidative stress markers during the psychotic transition
Victoria Rambaud, Ariel Frajerman, Margot Fournier, Anton Iftimovici, Daniella Dwir, Ines Khadimallah, Oussama Kebir, Aude Marzo, Marie-Odile Krebs, Boris Chaumette,
Volume 186,2025, Pages 137-144, https://doi.org/10.1016/j.jpsychires.2025.04.002.
https://www.sciencedirect.com/science/article/pii/S0022395625002237 - Schizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits.
Iftimovici, A., Martinez, G., Victor, J., Bendjemaa, N., Jantac, C., Danset-Alexandre, C., Amado, I., Pina-Camacho, L., Chaumette, B., Fatjó-Vilas, M., Fañanás, L., Duchesnay, E., & Krebs, M. O. (2025).
Schizophrenia bulletin, sbae202. Advance online publication. https://doi.org/10.1093/schbul/sbae202
https://pubmed.ncbi.nlm.nih.gov/39756426/ - Systematic Review of Self-Assessment Scales for Negative Symptoms in Schizophrenia
Métivier, L., & Dollfus, S. (2025)
Brain Sci. 2025 Jan 31;15(2):148. doi:10.3390/brainsci15020148. PMID: 40002481; PMCID: PMC11852625.
https://pubmed.ncbi.nlm.nih.gov/40002481/
2024
- Supervised Diagnosis Prediction from Cortical Sulci: Toward the Discovery of Neurodevelopmental Biomarkers in Mental Disorders
Auriau, P., Grigis, A., Dufumier, B., Louiset, R., Gori, P., Mangin, J.-F., Duchesnay, E., (2024)
IEEE International Symposium on Biomedical Imaging (ISBI), Athens, Greece, 2024, pp. 1-5, doi: 10.1109/ISBI56570.2024.10635738.
https://ieeexplore.ieee.org/document/10635738/authors#authors - How and why does deep ensemble coupled with transfer learning increase performance in bipolar disorder and schizophrenia classification?
Petiton, S., Grigis, A., Dufumier, B., Duchesnay, E., (2024)
EEE International Symposium on Biomedical Imaging (ISBI), Athens, Greece, 2024, pp. 1-5, doi: 10.1109/ISBI56570.2024.10635777.
https://ieeexplore.ieee.org/document/10635777 - Predicting treatment resistance in schizophrenia patients: Machine learning highlights the role of early pathophysiologic features.
Barruel, D., Hilbey, J., Charlet, J., Chaumette, B., Krebs, M. O., & Dauriac-Le Masson, V. (2024).
Schizophrenia research, 270, 1–10. https://doi.org/10.1016/j.schres.2024.05.011
https://pubmed.ncbi.nlm.nih.gov/38823319/ - Impact of minimal self disorders on naturalistic episodic memory in first-episode psychosis and parallels in healthy individuals with schizotypal traits
Yeh, D., Penaud, S., Gaston-Bellegarde, A., Scoriels, L., Krebs, M. O., & Piolino, P. (2024).
Frontiers in psychiatry, 15, 1469390.PMID: 39605999; PMCID: PMC11598521 https://doi.org/10.3389/fpsyt.2024.1469390
https://pubmed.ncbi.nlm.nih.gov/39605999/
- Cortical activations associated with spatial remapping of finger touch using EEG.
Alouit A, Gavaret M, Ramdani C, Lindberg PG, Dupin L. Cereb Cortex. 2024 Apr 1;34(4):bhae161. doi: 10.1093/cercor/bhae161. PMID: 38642106
https://pubmed.ncbi.nlm.nih.gov/38642106/ - Genetic and Neurodevelopmental Markers in Schizophrenia-Spectrum Disorders: Analysis of the Combined Role of the CNR1 Gene and Dermatoglyphics.
Guardiola-Ripoll, M., Sotero-Moreno, A., Chaumette, B., Kebir, O., Hostalet, N., Almodóvar-Payá, C., Moreira, M., Giralt-López, M., Krebs, M. O., & Fatjó-Vilas, M. (2024).
Biomedicines, 12(10), 2270. https://doi.org/10.3390/biomedicines12102270
https://pubmed.ncbi.nlm.nih.gov/39457583/ - Cognitive impairment in the schizophrenia spectrum: exploring the relationships of the g-factor with sociodemography, psychopathology, neurodevelopment, and genetics.
Yeh D, He Q, Krebs E, Iftimovici A, Martinez G, Bourgin-Duchesnay J, Mouaffak F, Danset-Alexandre C, de Gasquet M, Jantac C, Bendjemaa N, Chaumette B, Krebs MO, Scoriels L
Psychological Medicine, 1–12.doi:10.1017/S0033291724002538
https://www.cambridge.org/core/journals/psychological-medicine/article/cognitive-impairment-in-the-schizophrenia-spectrum-exploring-the-relationships-of-the-gfactor-with-sociodemography-psychopathology-neurodevelopment-and-genetics/65032705A29AC0A4E076EABC0362B24B - Neurodevelopmental predictors of treatment response in schizophrenia and bipolar disorder
Anton Iftimovici1, Emma Krebs, William Dalfin, Adrien Legrand, Linda Scoriels, Gilles Martinez, Narjes Bendjemaa, Edouard Duchesnay, Boris Chaumette and Marie-Odile Krebs
Psychological Medicine 1–12. https://doi.org/10.1017/S0033291724001776
https://psy-care.fr/wp-content/uploads/2024/10/Neurodevelopmental_predictors_of_treatment_respons.pdf - From Adolescence to Adulthood: Understanding Care Trajectories in an Early Detection and Intervention Centre in France
Marchini, S., Laroche, M.-A., Nemorin, H., Morin, V., Tanguy, G., Lucarini, V., Iftimovici, A., Chaumette, B., Krebs, M.-O. and Charre, M. (2024), Early Intervention in Psychiatry. https://doi.org/10.1111/eip.13605
https://onlinelibrary.wiley.com/doi/10.1111/eip.13605 -
SemOntoMap: A Hybrid Approach for Semantic Annotation of Clinical Texts
Ons Aouina, Jacques Hilbey, Jean Charlet.
Studies in Health Technology and Informatics, 2024, pp.1839-1843. ⟨10.3233/SHTI240789⟩. ⟨hal-04697348⟩
https://hal.science/hal-04697348v1 - Language in interaction: turn-taking patterns in conversations involvingindividuals with schizophrenia
Valeria Lucarini, Martine Grice, Simon Wehrle, Francesco Cangemi, Francesca Giustozzi, Stefano Amorosi, Francesco Rasmi, Nikolas Fascendini, Francesca Magnani, Carlo Marchesi, Linda Scoriels, Kai Vogeley, Marie-Odile Krebs, Matteo Tonna,
Psychiatry Research,Volume 339,2024, 116102, ISSN 0165-1781, https://doi.org/10.1016/j.psychres.2024.116102.
https://psy-care.fr/wp-content/uploads/2024/08/turn_taking_psy_res.pdf - Revealing the Unseen: Detecting Negative Symptoms in Students
Métivier L., Mauduy M, beaunieux H., Dollfus S.
2024 J. Clin. Med. 2024, 13, 1709. https://doi.org/10.3390/jcm13061709
https://www.mdpi.com/2077-0383/13/6/1709
2023
-
An Ontology Design Pattern for Modeling Experimental Paradigms
Stud Health Technol Inform. 2023 Jun 29;305:180-183. doi: 10.3233/SHTI230456.PMID: 37386990
https://pubmed.ncbi.nlm.nih.gov/37386990/ -
Ontology-Based Semantic Annotation of French Psychiatric Clinical Documents
Stud Health Technol Inform. 2023 May 18;302:793-797. doi: 10.3233/SHTI230268.PMID: 37203497
https://pubmed.ncbi.nlm.nih.gov/37203497/ -
Ontological Modeling of Clinical Study Forms
Stud Health Technol Inform. 2023 May 18;302:745-746. doi: 10.3233/SHTI230253.PMID: 37203483
https://pubmed.ncbi.nlm.nih.gov/37203483/ - Asynchronous neural maturation predicts transition to psychosis
Iftimovici, A., Bourgin, J., Houenou, J., Gay, O., Grigis, A., Victor, J., Chaumette, B., Krebs, M. O., Duchesnay, E., & ICAAR-plus Study Group (2023). Psychiatry and clinical neurosciences, 10.1111/pcn.13612. https://doi.org/10.1111/pcn.13612
https://pubmed.ncbi.nlm.nih.gov/37904327/ - Longitudinal MicroRNA Signature of Conversion to Psychosis
Iftimovici A, He Q, Jiao C, Duchesnay E, Krebs MO, Kebir O, Chaumette B.
Schizophr Bull. 2023 Aug 22:sbad080. doi: 10.1093/schbul/sbad080
https://pubmed.ncbi.nlm.nih.gov/37607340/ - A tablet-based quantitative assessment of manual dexterity for detection of early psychosis
Quentin Le Boterff, Ayah Rabah, Loïc Carment, Narjes Bendjemaa, Maxime Térémetz, Anaëlle Alouit, Agnes Levy, Guillaume Tanguy, Valentine Morin, Isabelle Amado, Macarena Cuenca, Guillaume Turc, Marc A. Maier, Marie-Odile Krebs and Påvel G. Lindberg
Frontiers in Psychiatry DOI: 10.3389/fpsyt.2023.1200864
https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1200864/full - The impact of BDNF on the cognitive functions of Ultra-High Risk patients: anexploratory study
Alexandre Couturier, Boris Chaumette, Oussama Kebir, Anton Iftimovici, Emma Krebs, Qin He, Chuan Jiao, Marie-Odile Krebs, Linda Scoriels, Ariel Frajerman,
Schizophrenia Research, 2023, https://doi.org/10.1016/j.schres.2022.11.016.
(https://www.sciencedirect.com/science/article/pii/S0920996422004327)
- EEG Microstates Imbalance across the Spectrum of Early Psychosis, Autism, and Mood Disorders
Anton Iftimovici1, Angela Marchi, Victor Férats, Estelle Pruvost-Robieux, Eléonore Guinard, Valentine Morin, Yannis Elandaloussi, Arnaud D’Halluin, Marie-Odile Krebs, Boris Chaumette, Martine Gavaret
European Psychiatry DOI: https://doi.org/10.1192/j.eurpsy.2023.2414
https://www.cambridge.org/core/journals/european-psychiatry/article/eeg-microstates-imbalance-across-the-spectrum-of-early-psychosis-autism-and-mood-disorders/9B0A40F661344485CDDE4A885B52AFA2#article - Membrane Lipids in Ultra-High-Risk Patients: Potential Predictive Biomarkers of Conversion to Psychosis
Frajerman, Ariel, Boris Chaumette, Dominique Farabos, Gaétan Despres, Christelle Simonard, Antonin Lamazière, Marie-Odile Krebs, and Oussama Kebir
Nutrients. 2023; 15(9):2215. https://doi.org/10.3390/nu15092215
https://www.mdpi.com/2072-6643/15/9/2215 - Abnormalities in one-carbon metabolism in young patients with psychosis
Ariel Frajerman, Marie Urban, Fabrice Rivollier, Marion Plaze, Boris Chaumette, Marie-Odile Krebs, Linda Scoriels
Frontiers in Psychiatry,
https://doi.org/10.3389/fpsyt.2023.1128890
https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1128890/full -
Validation of the French version of the Global Functioning: Social and Global Functioning: Role Scales in adolescents and young adults seeking help in early intervention clinics
Valeria Lucarini, Mathilde Kazes, Emma Krebs, Valentine Morin, Maud Godignon, Marie De Gasquet, Trang Ton, Marion Féron, Guillaume Tanguy, Agnès Lévi, Cécile Bellot, Dominique Willard, Andrea M Auther, Barbara Cornblatt, Marie-Cécile Bralet, Marie-Odile Krebs
Early intervention in psychiatry, 10.1111/eip.13427. Advance online publication. https://doi.org/10.1111/eip.13427
2022
- Oxidative Stress and Emergence of Psychosis
Victoria Rambaud, Aude Marzo and Boris Chaumette
Antioxidants 2022, 11, 1870. https://doi.org/10.3390/antiox11101870
https://www.mdpi.com/2076-3921/11/10/1870/htm - A novel tablet-based application for assessment of manual dexterity and its components: a reliability and validity study in healthy subjects
Ayah Rabah, Quentin Le Boterff, Loïc Carment, Narjes Bendjemaa, Maxime Térémetz, Lucile Dupin, Macarena Cuenca, Jean-Louis Mas, Marie-Odile Krebs, Marc A. Maier & Påvel G. Lindberg
J NeuroEngineering Rehabil 19, 35 (2022). https://doi.org/10.1186/s12984-022-01011-9
https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-022-01011-9#citeas - Temporal Medical Knowledge Representation using ontologies
Hilbey J, Aimé X., Charlet J.
Studies in Health Technology and Informatics, IOS Press, 2022 PMID: 35612092 DOI: 10.3233/SHTI220470
https://pubmed.ncbi.nlm.nih.gov/35612092/ -
The BMS-LM ontology for biomedical data reporting throughout the lifecycle of a research study: From data model to ontology
Raboudi, A., Allanic, M., Balvay, D., Hervé, P.-Y., Viel, T., Yoganathan, T., Certain, A., Hilbey, J., Charlet, J., Durupt, A., Boutinaud, P., Eynard, B., Tavitian, B.
Studies in Health Technology and Informatics, IOS Press, 2022 https://doi.org/10.1016/j.jbi.2022.104007
https://www.sciencedirect.com/science/article/abs/pii/S1532046422000235?via%3Dihub - Dysmaturational Longitudinal Epigenetic Aging During Transition To Psychosis
2021
- Shared Biological Pathways between Antipsychotics and Omega-3 Fatty Acids: A Key Feature for Schizophrenia Preventive Treatment?
Ariel Frajerman, Linda Scoriels, Oussama Kebir and Boris Chaumette
Int. J. Mol. Sci. 2021, 22(13), 6881, 26 June 2021
https://www.mdpi.com/1422-0067/22/13/6881/htm - Machine learning and natural language processing in mental health : Systematic Review
Aziliz Le Glaz ; Yannis Haralambous ; Deok-Hee Kim-Dufor ; Philippe Lenca; Romain Billot ; Taylor C Ryan ; Jonathan Marsh ; Jordan DeVylder ; Michel Walter ; Sofian Berrouiguet ; Christophe Lemey
Journal of Internet and Medical Research, Vol 23, No 5 (2021): May
https://www.jmir.org/2021/5/e15708/ - Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis
Qin He, Célia Jantac Mam-Lam-Fook, Julie Chaignaud, Charlotte Danset-Alexandre, Anton Iftimovici, Johanna Gradels Hauguel, Gabrielle Houle, Calwing Liao, ICAAR study group, Patrick A. Dion, Guy A. Rouleau, Oussama Kebir, Marie-Odile Krebs & Boris Chaumette
Transl Psychiatry 11, 518 (2021)
https://www.nature.com/articles/s41398-021-01624-z
2020
- A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis
Boris Chaumette, Sarojini M Sengupta, Martin Lepage, Ashok Malla, Srividya N Iyer, Oussama Kebir, ICAAR study group; Patrick A Dion, Guy A Rouleau, Marie-Odile Krebs, Jai L Shah, Ridha Joober
Schizophr Res. 2020 Jul 2;S0920-9964(20)30371-6. doi: 10.1016/j.schres.2020.06.019.
https://pubmed.ncbi.nlm.nih.gov/32624350/ - Stress, Cortisol and NR3C1 in At-Risk Individuals for Psychosis: A Mendelian Randomization Study
Anton Iftimovici, Oussama Kebir, Qin He, Thérèse M Jay, ICAAR Study Group; Guy A Rouleau, Marie-Odile Krebs , Boris Chaumette
Front Psychiatry 2020 Jul 10;11:680. doi: 10.3389/fpsyt.2020.00680. eCollection 2020.
https://pubmed.ncbi.nlm.nih.gov/32754072/ - Dysregulation of peripheral expression of the YWHA genes during conversion to psychosis
Fanny Demars, Oussama Kebir, Aude Marzo, Anton Iftimovici, Catherine Schramm, ICAAR Study Group; Marie-Odile Krebs, Boris Chaumette
Sci Rep. 2020 Jun 17;10(1):9863. doi: 10.1038/s41598-020-66901-1.
https://pubmed.ncbi.nlm.nih.gov/32555255/
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